Necessary to gaining mechanics based insight into the vascular response is the utilization and visualization of in vivo intravascular imaging and metrics to validate sophisticated in-silico predictions. CBSET, in collaboration with MIT, has significant expertise with pre-clinical study design, developme1.nt and set-up, in vivo imaging and vascular reconstruction techniques. Utilizing this expertise, one can take the input state of the pre-clinical setup, including (but not limited to) device state and vascular morphology and constituents, and compare the outputs of the InSiSt platform metrics with the outputs of the pre-clinical study, including (but not limited to) vascular and device states.