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    InSilc Plenary Meeting – Galway, Ireland

    The Biomechanics Research Centre (BioMEC) at NUI Galway will host the next plenary meeting of the InSilc Consortium in the Alice Perry Engineering Building on the 5th and 6th July

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  • Funding

    The project has received funding from the European Union’s Horizon 2020 research and innovation programme

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  • The InSilc Project

    The aim of InSilc: In-silico trials for drug-eluting BVS development and evaluation is to develop an in-silicoclinical trial (ISCT) platform for designing, developing and assessing drug-eluting bioresorbable vascular scaffolds (BVS),

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  • InSilc Kickoff Meeting

    The kick-off meeting for InSilc project will take place on 28th November in Hotel du Lac, Ioaninna, Greece

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  • Who are we?

    This is the excerpt for a featured post.

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InSilc Degradation Module

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Compared to permanent BMSs, the design of the next-generation of drug-eluting BVS is complicated by the range of interacting physiochemical parameters that control material degradation in both polymer- and metal-based devices. In the case of synthetic polymers, bulk degradation takes place through a two-phase autocatalytic process, initiated by chemical hydrolysis of the polymer chains, which alters the pH in the local environment, in-turn accelerating the rate of hydrolytic breakdown of the polymer Degradation in metal-based devices generally takes place through an electrochemical process, whereby the alloying elements and an electrolyte form a galvanic cell, which results in heavily localised surface-based pitting corrosion adjacent to the cathode. Capturing the effects of the in vivo environment on bulk- or surface-based degradation mechanisms of polymer and metal-based bioresorbable materials through computational simulation presents significant challenges. The current state-of-the-art in degradation modelling of drug-eluting BVS has largely used phenomenological models to capture material behaviour. In the case of polymer-based degradation, continuum damage mechanics approaches have been developed that capture the effect of polymer chain scission through a degradation damage variable, that operates on materials parameters of the chosen constitutive law. Similarly, metal-based corrosion has been captured through the use of continuum damage mechanics, whereby a corrosion kinetic parameter controls the load-bearing capacity of surface elements.