InSilc Mechanical Modelling Module

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In order to suitably describe the mechanical response of BVSs, the Insist methodology will include:

  • Numerical solver: an explicit formulation will be adopted, since the model has to be used also for the drug-eluting BVS deployment simulations within coronary arteries, where complex geometry and contacts (e.g. bifurcations with multiple stents) are present
  • Material modelling: we will adopt the most accurate constitutive model available into the literature, using non-linear viscoplastic model for polymeric BVS (e.g. PLLA) and non-linear elastoplastic model for metallic BVS (e.g. magnesium). For the BVS backbone material device-specific mechanical properties will be used, while literature data will be assumed for the drug-loaded polymeric coating (being very small the coating thickness, this is not expected to significantly affect the structural behaviour of BVS). Possible anisotropic behaviour will be accounted for, according to experimental data.
  • Crimped configuration: we will start from the post-laser cutting geometry (to be properly deduced if unknown) and simulate the crimping, since this create proper residual stresses and strains within the struts.
  • Balloon: based on our previous studies we will use a simplified folding and unfolding for the balloon.

By using an accurate and device-specific mechanical modelling, in Insist we will be able to replace all the mechanical in vitro tests required for the BVS by technical with an efficient in-silico protocol.