FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS
Foundation for Research and Technology Hellas (FORTH): FORTH established in 1983, is one of the largest research centers in Greece with well – organized facilities and highly qualified personnel. Over the years, FORTH has become one of the top European research centers, thanks to its high impact research results and its valuable socioeconomic contribution.
The work in the inSilc project will be undertaken by the Unit of Medical Technology & Intelligent Information Systems (MedLab). MedLab is a highly innovative and self-contained research unit strongly activated in the fields of Biomedical Engineering and development of Intelligent Information systems. It has an internationally acknowledged excellence in conducting high quality scientific research and developing innovative Information Technology (IT) applications, products and services. Most of the Unit activities are based on international collaborations in the framework of European and Nationally funded projects (FP5, FP6, FP7, Horizon 2020). MedLab’s research activities cover a variety of subjects and they are classified into the following domains: Biomedical Research, Multi-scale Predictive modelling, Automated Diagnosis – Processing of Biomedical Signals/Images, Development of Wearable Devices, Decision Support Systems, Bioinformatics, Data mining, and Big Data.
THE UNIVERSITY OF SHEFFIELD
University of Sheffield (USFD) is a Russell Group research university with over 26,000 students, including 5,000 postgraduate students. USFD has an international reputation for excellence in research and teaching. Its excellence is reflected in national assessments of university academic performance. The University has close links with industry, commerce and the professions, and it achieves consistent success in attracting research grants from regional, national and international organizations, including the EU. As part of its overall strategy, the University is committed to maintaining its strong involvement in European programs and enhancing the European dimension of its work.
Contributions to InSiSt at USFD will be made in the Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB). CISTIB is an international and interdisciplinary research centre. CISTIB carries out research at the cross roads of computational imaging and modelling. As an enabler of new science and clinical and industrial translation, CISTIB has provided continued development to GIMIAS (Graphical Interface for Medical Image Analysis and Simulation, http://www.gimias.org), an open-source workflow-oriented environment focused on biomedical image computing and modelling. More details are available at: http://www.cistib.org
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Erasmus Medical Center (ERASMUSMC) is located in Rotterdam, the Netherlands, and is an internationally recognized center for excellent, dedicated patient care, highly rated transfer of knowledge and high-quality knowledge development in the fields of illness and health. Erasmus MC is the largest and most versatile of the eight university medical centers in the Netherlands. Based on the international citation index, Erasmus MC is the leader among university medical centers in the Netherlands. At present, Erasmus MC is one of the 40 best research institutes worldwide.
The Biomechanics Laboratory group, part of the Thoraxcenter of the Erasmus Medical Center, studies the biomechanics of the development of atherosclerotic plaques in the human carotid and coronary arteries.
POLITECNICO DI MILANO
Politecnico di Milano (POLIMI) is a scientific-technological university, established since 1863, where engineers, architects and designers are educated. POLIMI has over 1,100 professors and nearly 40,000 students over 7 campuses.
Part of the research at the POLIMI (www.polimi.it) is based Life Sciences and Technologies The research group is based in the Laboratory of Biological Structure Mechanics (LaBS), created in 2000, where a wide experience is available on materials and structural numerical modelling for endovascular prostheses as well biomechanical experimental testing equipment. LaBS main investigation topics are tissues, biomaterials, prostheses and medical devices, with special reference to mechanical phenomena. In particular, POLIMI has a relevant expertise in designing and modelling medical devices in the cardiovascular field. LaBS offers an overall surface of about 600 m2, equipped with laboratories and a computer centre. LaBS is currently running several commercial and research projects and has participated in a number of European projects (among which MeDDiCA Marie Curie ITN, VPH-MIP, RT3S – ‘Real Time Simulation for Safer vascular Stenting’).
CONSIGLIO NAZIONALE DELLE RICERCHE
CNR Institute of Clinical Physiology is a Center for basic, clinical, technological and epidemiological research. This multidisciplinary translational approach has been the key strategy of driving collaborations through the years on a flexible and problem-solving basis. The main interest of the Institute is in the field of cardiovascular diseases, which are dealt with through a multiorgan and multisystem prospective, covering associated pathologies of the lungs, kidneys, and the neuro-endocrine and metabolic systems. Research is mainly developed in the area of physiopathology and methodology, in which multidisciplinary projects merge in the fields of experimental and clinical medicine, in line with the tradition of the Institute. CNR has carried out several pharmacological and medical trials in the cardiovascular disease field, developing during its activity a wide clinical database for selection of study populations, characterized in terms of genetics/biohumoral data as well as of clinical imaging repository (Echo, MRI, CT, Angiography).
MEDIOLANUM CARDIO RESEARCH S.R.L.
Mediolanum Cardio Research (MCR) Srl is an independent Contract Research Organisation (CRO) established in Milano (Italy). MCR was founded in 2002 with the aim of supporting no-profit research projects developed by a group of interventional cardiologists. Since then, MCR have gained extensive experience as Clinical Research Organization providing services for regulatory authorizations, project management, monitoring, data management and statistics for sponsored and no-profit clinical trials both pharmacological as well as with Medical Devices. In addition, MCR has an internal Core-lab specialised in Quantitative Coronary Angiography (QCA) readings.
FEOPS was founded in 2009 as a spin-off company from Ghent University and is a recognized pioneer in the field of physics-based simulations for minimally invasive cardiovascular devices and procedures. FEOPS offers services to medical device companies as well as to medical specialists and physicians around the world, and is the first company to be cleared to market with a patient-based simulation model for pre-operative planning. The CE marked TAVIguideTM technology uses the gold-standard pre-operative MSCT images to provide physicians with unique additional insights into how a specific transcatheter aortic valve will interact with a specific anatomy, which helps to optimize device size selection and positioning. Physicians can submit patient cases through a secured web application, and use the same platform to view the simulation results in three dimensions. A user-friendly interface allows physicians to inspect and compare the model predictions for various device sizes and positions.
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Biomechanics Research Centre, NUI Galway, has a vibrant research culture and has created a reputation for research excellence in the areas of intelligent systems, advanced materials, biomedical engineering, clean energy and environment, and communication technologies. The University has attracted over 50 Million Euro EU funding. In 2013, NUIG was awarded the HR Excellence in Research Logo by the European Commission. The Biomechanics Research Centre at NUI Galway, led by Prof. Peter McHugh has more than 20 years’ experience in research, and the team are world leaders in computational and experimental mechanics. The Biomechanics Research Centre at NUI Galway is at present host to over 40 principal investigators, research fellows, postdoctoral researchers and graduate research students, who are involved in active multi-disciplinary collaborations across the University and with industrial and academic institutions nationally and internationally. Our team has an extensive track record in securing research funds nationally and internationally as well as training and developing graduates for future leadership in the life sciences sector.
BIOENGINEERING RESEARCH AND DEVELOPMENT CENTER
BIOIRC is a research centre devoted to computational modelling and software development for various problems in engineering and bioengineering. The research is largely based on the finite element method applied to solids, fluids, modelling of physical fields, multiphysics, and various coupled problems. Also, discrete particle methods, such as dissipative particle dynamics, are developed and coupled with continuum models in multiscale schemes. The solvers are accompanied by state-of-the art computer graphics as well as image processing methods and 3D medical image reconstructions. BIOIRC achieved significant results in the field of bioengineering which are prominent at the national and international level. The deputy director of the centre is Prof. Nenad Filipovic who has rich experience in computer simulation of the cardiovascular system, muscle, bone and tissue mechanics. A large number of scientific publications and results have been issued as the result of collaboration with different national and international partners, spanning from blood flow modelling, cartilage muscle and tissue mechanics, thrombosis and plaque growth modelling, to molecular diffusion and multiscale modelling. The Centre is capable, with its hardware, software and researchers, to coordinate activities within the project.
UNIVERSITY OF IOANNINA
University of Ioannina (UOI) was founded in 1964, as a charter of the Aristotle University of Thessaloniki and became an independent university in 1970. As of 2014, there is a student population of approximately 15,000 active students enrolled at the university and more than 580 Faculty members. University of Ioannina is one of the leading academic institutions in Greece. According to the 2015 Leiden rankings, the University of Ioannina is ranked #2 overall in Greece.
The Medical School of Ioannina is one of the seven Medical Schools in Greece. It was founded in 1977 and its evolution is believed to be impressive, considering its achievements and reputation, within such a short time period. The medical education program lasts at least 6 years, with 200 students entering the Medical School via National-wide exams every year. There are also several postgraduate and Ph.D. programs. It has an increasing number of faculty members, aiming to serve its missions in education, clinical practice and research.
CONCORD BIOMEDICAL SCIENCES AND EMERGING TECHNOLOGIES
CBSET is a not-for-profit contract research organization (CRO) mainly dedicated to biomedical research, training and early-stage medical device testing and computational modeling. This AAALAC-accredited, Good Laboratory Practice (GLP) facility works in close collaboration with the MIT DCM to provide advanced animal care and interventional experiments. It is located in approximately in 35,000 sq. ft. state of the art facility that was purpose built in 2006-2007 for the conduct of pre-clinical interventional cardiology procedures. These laboratory and vivarium facilities are fully GLP compliant and AAALAC accredited. CBSET is equipped with experimental benches to carry out all the necessary methods and experiments proposed in the grant including tissue culture experiments, tissue processing, immunohistochemical processing, immunocytochemical staining, morphometric analysis, computer-aided microscopy and tissue assays. The extensive research facilities and the state-of-the-art equipment enable the investigators to conduct cell culturing, tissue processing, embedding, grinding, staining, imaging and morphometric analysis, qualitative histopathological assessment and scoring, microgrinding, immunohistochemistry, and quantitative fluorescent and Scanning Electron Microscopy (SEM).
BOSTON SCIENTIFIC LIMITED
Boston Scientific Ltd (BSL) is a leading innovator of medical solutions that improve the health of patients around the world. It was founded in 1979 by Pete Nicholas and John Abele. It was founded in 1979 by Pete Nicholas and John Abele, employs approximately 24,000 employees worldwide, generating an annual revenue of $7.2 billion revenue (2013), with approximately $1 billion of this invested in R&D (2013). Boston Scientific’s products and technologies are used to diagnose or treat a wide range of medical conditions, including heart, digestive, pulmonary, vascular, urological, women’s health, and chronic pain conditions. It continues to innovate in these areas and is extending innovations into new geographies and high-growth adjacency markets. In Ireland, Boston Scientific Limited is located at three location Galway, Cork, and Clonmel and is one of the largest employers in the country. The Galway site is the largest facility in Boston Scientific, and has R&D and manufacturing functions. It was established in 1994 and manufactures 45 different products supporting €1bln revenue and employs >3000 people.