Animal model systems are the translational link between the bench-top experiment and the clinical trial. Their utilization is vital but can be made much more efficient through complementary validated in-silico experimentation. However, there is a distinct lack of correlation to physics-based simulations that precisely account for mechanical factors of blood flow, radial scaffolding forces, cardiac motion to name but a few key aspects. This correlation becomes even more vital to understand with the advent of latest generation of drug-eluting BVS and their associated dynamic structural changes, as currently ambiguity in the clinical results prevail.